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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN18
All Species:
1.82
Human Site:
T435
Identified Species:
4.44
UniProt:
Q99952
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99952
NP_055184.2
460
50482
T435
D
V
A
G
G
A
Q
T
G
G
L
G
F
N
L
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S761
I
L
R
N
M
K
K
S
I
C
N
S
C
P
P
Rhesus Macaque
Macaca mulatta
XP_001093333
456
50339
G435
G
A
Q
T
G
G
L
G
F
N
L
R
I
G
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q61152
453
50183
N434
Q
T
G
G
L
G
F
N
L
R
I
G
R
P
K
Rat
Rattus norvegicus
NP_001013129
453
50088
N434
Q
T
G
G
L
G
F
N
L
R
I
G
R
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521024
682
72925
N638
C
P
S
P
V
S
S
N
G
S
G
K
T
L
L
Chicken
Gallus gallus
XP_001235234
775
85980
T635
S
S
V
P
P
S
V
T
S
N
D
S
V
R
L
Frog
Xenopus laevis
NP_001121240
511
57423
P475
G
G
K
W
W
Q
L
P
T
S
A
F
P
G
S
Zebra Danio
Brachydanio rerio
NP_001013470
513
57261
P448
S
M
N
R
D
S
Q
P
H
G
P
P
L
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
E758
R
M
S
A
S
S
K
E
Y
S
Y
V
D
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.1
94.7
N.A.
N.A.
75.8
74.7
N.A.
36.5
27.6
42.2
39.1
N.A.
N.A.
N.A.
N.A.
22.6
Protein Similarity:
100
38.7
96.5
N.A.
N.A.
82.6
82.3
N.A.
46.9
40.6
58.7
55.3
N.A.
N.A.
N.A.
N.A.
32.4
P-Site Identity:
100
0
13.3
N.A.
N.A.
13.3
13.3
N.A.
13.3
13.3
0
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
20
13.3
N.A.
N.A.
20
20
N.A.
26.6
20
0
33.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
10
0
10
0
0
0
0
10
0
0
0
0
% A
% Cys:
10
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% C
% Asp:
10
0
0
0
10
0
0
0
0
0
10
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
20
0
10
0
0
10
10
0
0
% F
% Gly:
20
10
20
30
20
30
0
10
20
20
10
30
0
20
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
10
0
20
0
10
0
0
% I
% Lys:
0
0
10
0
0
10
20
0
0
0
0
10
0
0
20
% K
% Leu:
0
10
0
0
20
0
20
0
20
0
20
0
10
10
30
% L
% Met:
0
20
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
0
0
0
30
0
20
10
0
0
10
0
% N
% Pro:
0
10
0
20
10
0
0
20
0
0
10
10
10
30
10
% P
% Gln:
20
0
10
0
0
10
20
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
10
10
0
0
0
0
0
20
0
10
20
10
20
% R
% Ser:
20
10
20
0
10
40
10
10
10
30
0
20
0
10
20
% S
% Thr:
0
20
0
10
0
0
0
20
10
0
0
0
10
10
0
% T
% Val:
0
10
10
0
10
0
10
0
0
0
0
10
10
0
0
% V
% Trp:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _